The Sequencing Initiative Suomi (The SISu project) is an international collaboration between research groups aiming to build tools for genomic medicine.
How to acknowledge the SISu database:
The Sequencing Initiative Suomi (SISu) project is an international collaboration between research groups aiming to build tools for genomic medicine. These groups are generating whole genome and whole exome sequence data from Finnish samples and provide data resources for the research community. Key groups of the project are from Universities of Eastern Finland, Oulu and Helsinki and The Institute for Health and Welfare, Finland, Lund University, The Wellcome Trust Sanger Institute, University of Oxford, The Broad Institute of Harvard and MIT, University of Michigan, Washington University in St. Louis, and University of California, Los Angeles (UCLA). The project is coordinated in the Institute for Molecular Medicine Finland at the University of Helsinki.
This SISU v4.0 (2016-04-19, GRCh37) release includes:
- 1 343 601 sites with 1 230 641 SNVs and 130 006 indels
- 10 490 Finnish samples from 10 cohorts that were sequenced in The Broad Institute of Harvard and MIT, Wellcome Trust Sanger Institute and Washington University in St. Louis
- Original sequencing was done using four different platforms (Agilent 1.1 refseq plus 3 boosters, Agilent sureselect 50mb, Illumina coding v1 and Nimblegen SeqCap EZ VCRome)
- Finnish enrichment and other information fields for custom filtering purposes now available
The SISu data resource currently covers exons only and data is restricted to autosomal SNPs and indels. Genome build used in this release is GRCh37. Minor allele frequencies before QC and after QC are provided.